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Milling media

Grinding involves the use of milling media. Ball mills such as planetary ball mill, attritors, and cryogenic milling are a few examples of the different types of milling media. Each of these media has advantages and disadvantages of its own. We will go over a few of the elements that influence the selection of milling media in this article. We'll also take a look at studies that have been done on how milling affects pharmaceutical materials that are soft and highly plastic.

Ball mills

The grinding media used in ball mills creates a fine powder from the material. They operate under the attrition and impact theory. Ball mills use a range of ball sizes. Hard materials will be crushed more quickly by small balls than by large ones.


Using a ball mill has a number of benefits. One of these is the grinding process's cyclical nature, which makes it appropriate for continuous operation. It can operate in both dry and wet environments, which is an additional benefit. Additionally, they are inexpensive to install from planetary ball mill suppliers.


Ball mills come in a variety of designs, from basic to sophisticated. But the machine itself is the same in essence. The volume of the mill may be decreased or increased depending on the type.


The material to be ground is fed into the ball mill through a chute or screw. After entering the mill, the material is ground by rolling balls over a cylinder. The balls can be made to resemble steel, rubber, ceramic, or other materials depending on the type.


Why choose Tianchuang Milling media?

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Studies on milling of soft and highly plastic pharmaceutical materials

Milling is an important process in the manufacture of fine drug particles. The process alters the particle size distribution and surface roughness. It is especially important for fine drug particles that are required in parenteral preparations. There are various milling techniques used for this purpose. This article provides an overview of the common milling techniques and the effects they have on the particle morphology, surface characteristics and performance.

Several studies have shown that milling-induced amorphization can enhance the solubility of several drugs. For example, piroxicam and naproxen have been found to exhibit improved solubility after milling. Besides increasing solubility, amorphization also improves compressibility.

In addition, milling may lead to structural disordering of the crystals. Such disordered crystals have a lowered thermodynamic stability and can amorphize during storage. Some of these amorphous regions can be thermodynamically unstable and may cause amorphous-crystalline interconversions.

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